Backgroud: Osteomyelitis is an inflammatory process of bone and bone marrow contents. Bone changes are primarily seen in the soft tissue followed by the calcified tissue. It is usually caused by pyogenic bacteria or mycobacterium. Objective: To determine the epidemiologic profile of patients with osteomyelitis admitted at a tertiary centre from 2006 to2016. Methodology: The present study was done retrospectively in which the data was collected from the year 2006- 2016 from a tertiary centre and analyzed epidemiologically. Result: The female patients outnumbered the male patients and most of the patients were in their 3rd and 4th decade. Also, the maxilla was more commonly affected thand mandible. Conclusion: The study helps in assessment of the local data of a tertiary centre which is important in optimizing the local therapeutic protocols.