Introduction: Skull is most commonly found and recovered intact among all the bones of the body. Though, anthropometric measurements can determine the gender of the individual, the morphometric analysis of the skull can also aid in gender determination. Morphometric analysis of maxillary sinus can be accurately measured using new imaging modalities like CBCT. Aims and Objectives: To assess the accuracy of maxillary morphometric parameters in gender determination. Materials and Methods: 200 maxillary sinus CBCT images were acquired retrospectively from the database to measure various parameters of the maxillary sinus. All measurements were carried out using CS softwareVer.3.3.11. All the values were recorded on an excel sheet and were subjected to statistical analysis. Results: Comparison of the measurements of maxillary sinus between males and females showed that the overall parameters were significantly greater in males than in females. The final result of the discriminative analysis shows that the ability of maxillary sinus to identify gender was 69% in males, 68% in females with an overall accuracy of 68.5%. Conclusion: Maxillary sinus morphometrics can be helpful in predicting the gender of the individual. The role of the oral radiologist in gender determination is important as his expertise in the field of head and neck radiology along with CBCT interpretations of maxillary morphometrics can help the forensic team to predict the gender of an individual.