Introduction: Sjögren's Syndrome is a complex and chronic autoimmune disease that affects the salivary and lacrimal glands, however the immunoregulatory and immunosuppressive effect of vitamins has been related to the disease. The objective was to know the vitamins related to the Sjögrens Primary Syndrome compared with a control group. Materials and Methods: A review was made in the PubMed database with the key words (Vitamin and Primary Sjogrens Syndrome and Primary Sjögrens Syndrome) without restriction of date until November 2, 2018, only studies conducted in humans and published in English were selected. Results: We identified 50 studies with the search criteria, 5 studies were conducted on animals and were excluded, 7 studies were written in a language other than English and were excluded, only 38 studies were eligible and 7 of them were included. The vitamins A, D, E, and 25 hydroxyvitamin D3 were analyzed in the pSS compared to a control group. Conclusion: The vitamins D are important to balance calcium, phosphorus for the development of bone tissue and in patients with pSS the musculoskeletal system may be affected.