Purpose: The aim of this study was to evaluate the effects of various drinks and toothbrushing on the color changes of esthetic restorative materials used in dentistry. Materials and Methods: Forty specimens were prepared from each of four restorative materials (nano-hybrid composite [IPS EMPRESS Direct ivoclar] composite resin [Tetric N-Ceram Bulk Fill,ivoclar], glass ionomer cement [Vivaglass CEM PL ivoclar ], composite resin [Tetric N-Ceram cavifil,ivoclar]). Specimens were divided into four groups for immersion in five different staining solutions (cola, chocolate milk, coffee, 7up and cherry juice). Each group was subdivided into brushing and non-brushing groups. The specimens in the brushing subgroups were brushed with toothpaste once a day using toothbrush. Color was measured using a Digital Shade Matching System DSMS, and color changes were calculated between baseline and 21 days, 1, 2, 3, 4, 5, 6 months. Results: All the solutions evaluated yielded color changes after 21 days, and these changes were significantly greater for glass ionomer cement than IPSS EMPRESS, composite bulkfill and composite resin (p < 0.006). Brushing no significantly difference for the color changes of restorative materials (p > 0.004). Conclusion: Chance for staining the esthetic restorative materials in a short period is low except GIC, and the brushing has no significant effect to prevent any discoloration for the esthetic restorations in a short period approximate one month.