Generally, many large tissue defects occur with surgery treatments of tumors in the maxillofacial region. Maxillofacial prosthesis application can be used as an alternative treatment for cases where plastic surgery reconstructions cannot be applied. While the retention of maxillofacial prostheses used to be provided generally via adhesive bands, adhesives in liquid or spray form, and tissue undercuts, the current treatment of an intra-oral edentulous condition is frequently conducted via osseo-integrated implants. The most significant problem facing the reinforcement of the facial implants is inadequate bone thickness. While the most suitable reinforcement points for implant are the temporal region and supraorbital edge, the bone thickness varies between 2.5 and 6mm for those regions. This article reviews the application of implants in different maxillofacial prostheses.