Radicular cyst is the most common odontogenic cystic lesion of inflammatory origin. It is also known as periapical cyst, apical periodontal cyst, root end cyst, or dental cyst. It arises from epithelial residues in the periodontal ligament as a result of inflammation. This condition is usually asymptomatic but can result in a slow-growth tumefaction in the affected region. Radiographically, the archetypal description of the lesion is a round or oval, well circumscribed radiolucent image involving the apex of the infected tooth. In the management of these lesions the endodontic treatment only is not sufficient and it should be associated with surgical management. This paper presents a case of endodontics cum surgical management of large radicular cyst in the maxillary anterior region with complete resorption of maxillary nasal floor.