Background: Candida infection today is highly prevalent, especially the increase in carriers of removable dentures and poor oral hygiene society. Aim: To evaluate the role of fluconazole and clotrimazole in treating oral candidiasis patients. Methods: Two hundred subjects suffering from oral candidiasis formed the study population. Microbiological culture confirmed the diagnosis of oral candidiasis. Study subjects were divided into Group A - subjects who were under treatment with fluconazole therapy, Group B - subjects who were on clotrimazole therapy. Follow up of the study subjects was done after 2 weeks of continuation of the treatment. Results: Among group A subjects, before starting the treatment, 164 (82%) of the them had moderate severity of clinical symptoms, whereas in group B, 148 (74%) of the subjects had moderate severity of symptoms. After the treatment, most 190 (95%) of the them were devoid of any symptom in group A, whereas such proportion was 172 (86%) in group B. In group A subjects, before and after the treatment, the colony count was 1376.4 and 10.8, respectively, whereas in the group II patients, the mean colony count was 854.1 and 23.3, respectively. Conclusion: Both fluconazole and clotrimazole were approximately equally effective while treating subjects having oral candidiasis.