Teeth are very important for the appearance of an individual. The colour of the teeth is also equally important as it as a harmony with surrounding environment such as skin, hair, eye colour. The purpose of this study was to assess the association between tooth shade and skin colour among dental college students. The present cross sectional study was carried on 140 undergraduate and post graduate Dental students. After recruiting study subjects based on study criterias, The shades of middle third of labial surface of permanent maxillary left or right central incisor were taken by using the Vita pan classic shade guide. Next, skin color/tone was matched by using the Ideal Balance Quick Stick makeup shades as a guide. Results were analyzed using chi square test and spearman’s correlation. There was a negative correlation between age and skin colour which was statistically significant (p = 0.023). Conversely, there was a positive correlation between age and tooth colour which was statistically significant (p = 0.017). There was a negative correlation between gender and skin colour (p=0.430). Similarly a negative correlation was observed between gender and tooth colour which was statistically non significant (p= 0.846). There was a negative correlation between skin colour and tooth colour which was statistically significant (p < 0.000). The results of this observational study suggest that there is a significant relationship between tooth shade and skin color. Based on the relationships skin color may be a useful guide for the selection of tooth shade.