The successful treatment of periapical inflammatory lesion depends on the reduction and removal of the offending organism. Periapical surgery is one of the alternative treatment, includes the curettage of all periapical soft tissues and sometimes application of different biomaterials to improve the new bone formation in the defect site. This case report present the management of the periapical inflammatory lesion using platelet-rich fibrin (PRF) which acts as a source of growth factors at the healing site. PRF is now becoming grippingly popular regenerative procedure either used alone or in addition with other regenerative materials. Besides being rich in platelet concentration, it is also a reservoir of many growth factors that promotes successful hard and soft tissue healing.