Few studies have assessed the real gain in satisfaction and quality of life of patients rehabilitated with full-arch implantsupported prosthesis. Here, a validated questionnaire (OHIP-14) was used to assess satisfaction and quality of life of patients using total upper and/or lower prosthesis who were rehabilitated with this type of prostheses. The sample consisted of 150 patients divided in three groups (Group 1 = lower protocol; Group 2 = upper protocol; and Group 3 = upper and lower protocol). Most of the answers were zero for all three groups. The intergroup analysis showed no significant difference in the total sum of questions. In the intragroup analysis, the total sum of questions was significantly smaller in the Upper and Lower Group. Time of use of fixed prosthesis accounts for over 30% of the variation in total OHIP-14. There was no influence of protocol location on OHIP-14 answers and, in general, the satisfaction of patients rehabilitated with implant-supported prosthesis is clear