Polymerization methods of acrylic resins have considerable effect on physical and mechanical properties like release monomer and porosity. The aim of this study was to investigate the release of residual monomer and porosity for acrylic denture base materials processed by different polymerization methods (heat and pour cured). Ten specimens were fabricated for each test. For release monomer test the samples were analyzed using gas chromatography with a flame ionization detector and for porosity test it was calculated by measurement of the specimen weight before its immersion in water and 7 days following immersion in water. Student t- test was performed to study the differences between the mean ratio of release monomer and porosity in heat-cured and pour-cured acrylic resin. The statistical analysis indicated highly significant differences in the mean rate of release monomer and porosity between pour-cured and heat-cured acrylic resin (P<0.001). As a conclusion, pour-cured acrylic processing method was significantly higher than heat-cured one in both residual monomer content and porosity.