The current study presents a case of iatrogenic mid-root perforation with a maxillary central incisor in a 59 -year-old female patient, with a history of trauma in that region. Perforations that occur in the mid-root region pose a challenge to the dentist due to inadequate access to the perforation site. Perforations also increase the chance of inflammatory reaction in the periodontal ligament. A concept for the repair of root perforations is presented using a resorbable collagen matrix which reconstructs the outer shape of the root and facilitates the adaptation of MTA. The current clinical case shows successful root perforation repair with follow up using aforementioned technique.