Friction is the vital aspect of Orthodontics which requires attention during all the phases of treatment, especially during the phase of space closure. In Orthodontics, space closure can be achieved by the sliding mechanics and/or the segmented arch mechanics. Though sliding mechanics is the most commonly used space closure mechanics, it has the disadvantage of generating the friction at the bracket-archwire interface which indirectly affects the desired tooth movement. Due to the universal acceptance of this type of mechanics, the role of friction in orthodontics has become the topic of interest. Thus, this article enlightens the role of friction in orthodontic tooth movement, with an approach to its clinical implication, the importance of frictional resistance, and the recent advances in orthodontics to reduce the friction.