Determining sex plays important role in the identification of the unknown person. The positive identification of human remains requires the matching of physical characteristics of the deceased with records of the physical characteristics made before death. Several methods may be used to produce identification with an aggregate high level of reliability. Sex determination is usually done by osteometry, DNA analysis and even by odontometric parameters. Aim of the study was to identify gender using measurements of mesiodistal crown width of the six maxillary anterior teeth (later added to derive combined mesiodistal widths), fronto-occipital head circumference, height, and diameter of the skull on a lateral cephalography. In this study, 100 persons were evaluated. After obtaining informed consent from the subject selected, measurements of mesiodistal crown width of the six maxillary anterior teeth (later added to derive combined mesiodistal widths), fronto-occipital head circumference, height, and diameter of the skull on a lateral cephalography were performed. Combined data, male, and female data were analyzed separately for binary logistical analysis for sex determination to the parameters recorded and discriminant function equation were derived for each parameter. In the present study mean values of all the parameters were calculated and showed a statistically significant variation between males and females. Discriminant function analysis was performed for all the variables which correctly classified 91% of the cases. Our Study suggests that the discriminant functional analysis has proved that the sex of unknown sex skull can be determined using above mentioned parameters. Studies at a large scale are in need to approve or disprove the above factor.