Shisha/ Waterpipe smoking has become a global epidemic, especially among youth. Health effects of WTS have not been studied extensively like the cigarette smoking. There is a dire need to study and document health effects of water pipe smoking in general and specifically on the oral cavity. 100 subjects under each category were studied: Exclusively Shisha smokers, Exclusively Cigarette smokers, Cigarette and shisha smokers and non-smokers. Along with the Arab population, Indian populations residing in UAE were also studied. After a brief explanation of the study, and obtaining a written consent signed from the study participants, a questionnaire was administered to collect data. A detailed case history was taken. Oral examination included soft tissue and hard tissue examination. Simplified oral hygiene was calculated. Respiratory problems and Sleep disturbance were mainly reported among shisha subjects. Moderate to mild stains and calculus along with periodontitis was recorded. Complains of bad breath and dry mouth was reported. One case of mixed white and red patches was noted in shisha smoker. The finding of our study could be substantial evidence that WTS alone has the potential to cause deleterious oral health effects and could even lead to pre-malignant lesions.