Several denture based materials have been used with a wide range of applications. Several techniques have been used in recent time to improve its properties for better durability, strength and working. To compare Impact Strength, Compressive Strength, Tensile Strength, Hardness and Dimensional accuracy of autopolymerized, postpolymerized microwave exposed autopolymerized and heat-cured denture base resins. Specimens were prepared by different modes of polymerization using autopolymerization technique, microwave post-polymerization treatment of autopolymerized acrylic resin and conventional water bath technique. The specimens were then subjected to various tests to evaluate strength (Impact, compressive, Tensile) and Hardness. There is statistically significant difference was found between mean impact strength and compressive strength of autopolymerized, postpolymerized microwave exposed autopolymerized and heat-cured denture base resin. There is no statistically significant difference between mean tensile strength of autopolymerized acrylic resin and postpolymerized microwave exposed autopolymerized acrylic resin (p=1.000) but a statistically significant difference was found between mean tensile strength of autopolymerized acrylic resin and heat-cured denture base resins (p=0.001). There was a statistically significant difference between mean Rockwell Hardness Number of autopolymerized acrylic resin and postpolymerized microwave exposed autopolymerized acrylic resin (p=0.005). A statistically significant difference was also found between mean Rockwell Hardness Number of postpolymerized microwave exposed autopolymerized acrylic resin and heat-cured denture base resins (p=0.001). Similarly, there was statistically significant difference was found between mean Rockwell Hardness Number of autopolymerized acrylic resin and heat-cured denture base resins (p=0.03). Comparison of mean linear dimensional change between autopolymerized and postpolymerized microwave exposed autopolymerized denture base resins showed no statistically significant difference in the mean dimensional change between the autopolymerized and postpolymerized microwave exposed autopolymerized denture base resins (p=0.051). Heat-cured acrylic resin exhibited the maximum values for Impact strength, Compressive Strength, Tensile Strength, Hardness and Dimensional Accuracy and Impact Strength of autopolymerized acylic resin improved after microwave postpolymerization treatment. Whereas, Hardness is decreased and Dimensional accuracy remained unaffected after the microwave postpolymerization treatment of autopolymerized acrylic resin.