Despite widespread use, little is known about the risk associated with insecticides exposure to human health hence, this study. 48 wistar rats (90-120g) were randomly grouped into six (n=8). All except Normal control (NC) were exposed to domestic insecticide fumes once every 48 hours. Group 2, insecticide control (IC) was exposed to (20% of 81.55mg/m3) 0.20mg/ml of DAKSH insecticide. Group 3, positive control (PC) was treated with a standard testosterone drug-Nugenix. Groups 4, 5 and 6 received 400mg/kg b.w each of crude extract (CE), ethylacetate and n-hexane fractions of Vernonia calvaona (VC) daily via orogastric intubation for 21 days. After administration, animal sacrifice and blood collection was done via cardiac puncture for analysis. The result presented a significant decrease (p<0.05) in testosterone of IC group compared to NC. Groups 3 and all treated groups effected progressive increase in testosterone concentration compared to IC group. FSH was significantly reduced (p>0.05) in IC and n-hexane fraction of VC compared to control. However, nugenix treated and ethylacetate fraction caused a remarkable increase in FSH compared to IC. WBC was significantly decreased (p<0.05) in IC and n-hexane groups compared to control. The Crude Extract treated group significantly increased WBC count compared to IC group. Histopathological studies of the testes showed varied levels of histological derangements in IC while Ethyl acetate treated group showed highest regenerative ability. This study revealed that insecticides adversely affected male gonads while the extracts showed ameliorative effects with the highest effect seen in ethyl acetate fraction in managing the insecticide induced damage.