Desmoplastic ameloblastoma (DA) is a rare subtype of ameloblastoma, exhibiting eloquent variation in its clinical, radiological and histologic appearance. In 2017 WHO classification of a head and neck tumour has further modified this entity and titled it as a histologic variant of conventional ameloblastoma. A tumour mimics benign fibro-osseous lesion for being often prevailing in the anterior region of jaws as a mixed radiopaque-radiolucent lesion. We present a case of desmoplastic ameloblastoma in a 55-year-old male with a painless swelling in the anterior region of right maxilla. Ct scan shows a mixed lesion with multilocular appearance. An incisional biopsy verified it to be a case of desmoplastic ameloblastoma. Partial maxillectomy was performed on the right side. The patient is on routine follow-up with no recurrence. The present case deserves emphasis because of its unfamiliar appearance, potentially aggressive nature and deceptive radiologic appearance maximizing the chances of misdiagnosis. So, the clinician should be alert enough to include desmoplastic ameloblastoma in the differential diagnosis of any lesion/growth with mixed radiolucent-radiopaque appearance having ill-defined borders and occurring in anterior maxilla or mandible.