The aim of this review was to evaluate literature on the efficacy of platelet-rich fibrin (PRF) as a sole grafting material in sinus floor augmentation. The main advantage of PRF is the avoidance of a second surgical site needed for the harvest of autologous bone. A PubMed search was carried out, limited to human studies for articles on PRF as a sole grafting material. 15 unique results were found. Out of 15, 5 results met our inclusion criteria. All the studies were non-comparative and were analyzed for sample size, case-selection criteria, surgical technique, evaluation criteria, success rates and follow-up period. PRF showed promising results as a grafting material and is a relevant biomaterial for natural bone regeneration. Further, clinical studies including control groups in the form of randomized controlled clinical trials are required to establish the efficiency of PRF as a grafting material in sinus lift procedures.