The aim of this study was to evaluate the dental students’ perceptions toward the use of social media (Twitter) in an orthodontic course and the impact of this technology for teaching and learning. An online questionnaire was developed to evaluate 4th year students’ knowledge, use, and perceptions of Twitter for teaching and learning in an orthodontic course at Riyadh Colleges of Dentistry and Pharmacy. 85 of the students completed the questionnaire. Of the respondents, 75% reported having used Twitter on a daily bases. 58% of them they didn’t think that they will like the use of twitter for teaching. After their experienced it, 82% they liked it. The students perceived the Twitter sessions as enjoyable and reported it improved their engagement in orthodontic class. The results of this study indicated that students agreed that the use of Twitter had enhanced the learning environment in the orthodontic course.