Platelet-rich fibrin (PRF) was first described by Choukroun et al. in France. It has been referred to as a second-generation platelet concentrate, which has been shown to have several advantages over traditionally prepared PRP. It’s a new generation of platelet concentrates geared to simplified preparation without biochemical blood handling. This article describes the evolution of this novel platelet concentrate and its applications in the field of Oral and Maxillofacial Surgery.