Vertical root fracture(VRF) is one of the common reasons for extraction of endodontically treated teeth. Though many options of saving such teeth were available, they were not of much success. Therefore the objective of this article is to discuss one such case. A 50 year old male patient reported with Vertical root fracture and 15 mm of periodontal probing depth in the distal aspect of 14. Radiographic examination indicated vertical root fracture. Dual cure nanoionomer cement, Ketac N100 was used to seal the fracture followed by guided tissue regeneration therapy with amniotic membrane. The use of dual cure nanoionomer cement and amniotic membrane showed favourable results as the pocket probing depth reduced to 5mm and bone formation was appreciated radiographically at 1 year. It can be concluded that the combination of dual cure nanoionomer and amniotic membrane may be a suitable approach in the management of Vertical root fracture since it remarkably improved the prognosis of the tooth.