Slums are available in the port area of Chittagong city. The general health conditions of the slum dwellers are very poor. This study was conducted to explore the possible association of different disorders of post area people with their life style and socio-demographic status. A survey based prospective observational study was performed at Chittagong from July 2017 to January 2018. A total of 200 (125 from port area and 75 from city area) were identified as a quite effective sample for this study. A self-administered questionnaire was delivered to the participants. Majority of the respondents were married male in this study. Illiterate, ill-educated and day laborer people were available in port area when compared with city area. 35.2% people’s monthly income was below Tk. 10000 with poor household condition in port area. Most of the people were drinker (51%) and smoker (71%) in port area when compared to the city area. The values were 21% and 48% accordingly in city area. Various types of sound and sleep related problems are more common in port area people. Different physical disorders like fever, stroke, diarrhea and chest pain were more frequent in the port area when contrast to the city area. Moreover, mental problems such as depression, frustration, restlessness, stress and over pressure are also more common in port area than city area. Poverty, illiteracy and low socio-economic status is associated with many adverse mental and physical health outcomes. Evidence-based planning, decision-making and practice can help improve the health status and quality of life of people.