Radiographic imaging is essential in diagnosis, treatment planning and follow-up in endodontics. The interpretation of the 2-D images can be confounded by superimposition of both teeth and supporting structures and the geometric distortion that is present. These problems are overcome by cone beam computed tomography (CBCT) which produces accurate 3-D images which can be used for pre-surgical assessment. The spatial relationship of the specific tooth root(s) undergoing the surgical procedure (and the associated bony destruction) to adjacent anatomical structures can be precisely assessed. The radicular cyst arises from epithelial remnants stimulated to proliferate by an inflammatory process originating from pulpal necrosis of a non-vital tooth. Radiographically, the classical description of the lesion is a round or oval, well circumscribed radiolucent image involving the apex of the tooth. Radicular cyst is usually sterile unless it is secondarily infected. This case report presents successful management of an infected radicular cyst associated with a permanent maxillary left central incisor (21) in a 38 year old male by complete enucleation of the cyst and using platelet rich fibrin (PRF) and bone graft to fill in the bony cavity to hasten the healing.