Multiple impacted permanent teeth are uncommon and were rarely reported in the literature till date. This clinical report describes a multidisciplinary approach for the oral rehabilitation of a young adult patient with an undiagnosed syndrome presenting multiple impacted permanent teeth, retained deciduous teeth and false gingival enlargement. The specific objectives of this treatment were to enhance esthetics and restore the masticatory function while importing a positive psychological impact to the patient. One of the most demanding aspects essential to long-term success of such cases involves the regular monitoring of the patients, while simultaneously fulfilling aesthetic and functional parameters.