PRF along with various additives like Bone graft (BG) and Mineral Trioxide Aggregate (MTA) enhances periapical healing. This comparative clinical study was taken up to evaluate the periapical healing potential of plasma rich fibrin (PRF) as scaffold along with MTA and bone graft. Two patients with a history of trauma and large periapical radiolucent lesion were selected for this study. After access opening and biomechanical preparation, involved teeth were obturated with gutta percha using AH plus sealer. Subsequently periapical surgery was carried out and PRF was prepared by collecting blood from the patients. In the first patient, a mixture of PRF and MTA was placed into the periapical defect, while in the second patient a mixture of PRF and BG was placed. At 1 month, 3 month, 6 month and 1 year follow up was done for evaluation of clinical and radiographic healing. Both the patients remained clinically asymptomatic. Radiographically healing was found to be better with PRF and BG combination.