Radicular cysts are one of the most common pathology of oral cavity that oral and maxillofacial surgeons come across in daily practice. It has different treatment options and an operating surgeon should be aware of them and tailor them for individual patients. Aim of this case was to successfully treat a large periapical lesion of maxilla. 44 year old patient came with a swelling of palate with associated pain and was planned for surgical management of the swelling following thorough investigations. Surgical management of the lesion included enucleation of lesion into to, followed by apicectomy and retrograde filling with Mineral Trioxide Aggregate. Periapical lesions being one of the common entity has to be treated meticulously by a good team approach and newer materials need to be evaluated to provide a cost effective treatment.