Combination syndrome when an edentulous maxilla is opposed by natural mandibular anterior teeth. The present article aims at recording the signs of combination syndrome in study population. This study was conducted in department of Prosthodontics in 2016. It included 160 patients having edentulous maxilla wearing maxillary denture and partially edentulous mandible wearing mandibular removable partial denture (Kennedy class I). They were assessed for various signs. 160 (30%) patients were found positive for combination syndrome out of 480 examined cases. Out of 160 patients, males were 75 and females were 85. Maximum cases were recorded for lack of maxillary denture adaptation (male- 13, female- 15). The need for replacement for maxillary denture was seen equally in 11 cases in males and females. Lack of mandibular denture adaptation was seen in males (9) and females (9). Growth of the tuberoisities was seen in 8 males and 10 females. Need for replacement for mandibular denture was seen in 10 males and 5 females. The difference was significant (0.02). Papillary hyperplasia was significantly higher in females (14) than males (7). Hypermobility of the anterior part of the maxilla was seen significantly higher in females (12) than males (6). 6 males and 2 females showed extrusion of lower anterior teeth. The difference was significant. Author concluded that the prevalence rate of combination syndrome was 30% with slight female predominance.