Current management of fracture healing does not involve ultrasound therapy. We describe a systematic review of randomized controlled clinical trials of low intensity pulsed ultrasound therapy for bone healing and its clinical efficacy in maxillofacial surgeries. We searched 3 electronic databases (MEDLINE, EMBASE, Cochrane Database of Randomised Clinical Trials) and selected studies done in the area of ultrasound therapy and fracture healing and evaluated separately. Therapeutic effects of ultrasound therapy have been studied in the past few decades and various clinical studies have been published, showing its beneficial results on bone healing and its mechanism of action. Ultrasound treatment is an innovative, noninvasive modality to enhance bone healing, with minimal side effects. It may be considered as an adjunct treatment of choice, in management of fractures, reconstructive surgeries and healing of bony pathologies. Further clinical trials are advised, to access its mechanism of action and application in surgeries of maxillofacial region.