Most common treatment modality for a missing teeth these days is either a denture or implant based prosthesis. Great level of patient satisfaction has also been achieved with these two treatment options but scientifically speaking, both of these aren’t biologically totally in coherence with the host system as the chances of foreign body rejection is always with them. Hence as the research continues in this modern era of dentistry, it is inevitable to open the roadway for an exact biologically duplicate model for what is to be replaced. Talking about the regenerative endodontics, various techniques have been employed for the same. But the most promising and encouraging technique has been the scaffold based regeneration. Three dimension scaffolds which mimic the cells natural extracellular matrix as close as possible are being extensively studied these days and have emerged as a promising option for the replacement of missing tooth with an entirely biological prosthesis, which can probably be called as a ―Bio-Tooth‖.