The existence of pesantren in responding to the development time to be able to give birth to reliable santri empowerment through the power of the brain (thinking), heart (faith), and hands (skills) is the main asset to form a santri personality capable of balancing to the development of time. Various skill activities in the form of trainings or workshops (daurah) which further deepen knowledge and work skills are the effort to broaden the knowledge of santri in the field of entrepreneurship, which constitutes one of the concrete breakthroughs to prepare santri as an individual in the community. This research is directed to answer, investigate, and analyze the management of the pond entrepreneurship at the Orphanage Foundation/Pondok Pesantren Al Mukhlisin Ciseeng, Bogor. The results show that the fish pond entrepreneurship was carried out through extra-curricular activities the Orphanage Foundation/Pondok Pesantren Al Mukhlisin Ciseeng, Bogor.