An increasing antimicrobial resistance among Klebsiella pneumoniae (K. pneumoniae) has been rapidly growing. The cross-sectional, analytical and descriptive study was conducted to investigate the current in vitro susceptibility pattern of clinically isolated K. pneumoniae. Patient data for 700 different clinical specimens were collected from the case records during October 2016 to March 2017. Following isolation and identification of 113 isolates of K. pneumoniae to the species level, antibiotic susceptibility pattern for all isolates was examined using standard Kirby-Bauer disk diffusion method. Among113 K. pneumoniae isolates, 25 (12.6%) and 88 (39.5%) were isolated from outpatients and inpatients respectively were considered for the study. The isolates showed high levels of resistance to Penicillin (100.0%), Ampicillin (96.5), first-generation cephalosporins (>92.0%), Nalidixic acid (93.8%), Erythromycin (96.5), Roxithromycin (99.1%). The isolates were less resistant to Amikacin (27.4%), Imipenem (29.2%). Good antibiotics activity against community-acquired (CA) compared to hospital-acquired (HA) isolates and the difference in resistant rate between them was found statistically significant for several antibiotics. A general increase in the resistance pattern of K. pneumoniae was detected to all the antibiotics that confirm the greatest and frightening problem in our country. Mechanisms for HA infection control measures must be evaluated to reduce pathogenic resistant bacterial strains spreading. Also, strike regulation of the antibiotics buying and intake by the public need to be applied.