This study comparatively evaluated the in vitro antioxidant activity and the hepato-protective effect of extracts of two locally consumed fruits, Dacryodes edulis (African pear) and Tetracarpidium conophorum (African walnut) in sodium arsenate exposed rats. Antioxidant activity was determined by spectrophotometric methods using 2, 2-diphenyl-2- picrylhydrazyl (DPPH) radical, hydrogen peroxide (H2O2) and malondialdehyde (MDA) assays. Total phenol, flavonoids and anthocyanins content of extracts were also determined. Results from the study indicated that DPPH and H2O2 scavenging capacity as well as percentage inhibition of MDA were significantly higher (P˂0.05) in extract of T. conophorum (48.34%, 46.9% and 53.5%, respectively) when compared with D. edulis extract (45.47%, 18.1% and 45.3%, respectively). The anthocyanins content was significantly higher (P˂0.05) in D. edulis extract than in T. conophorum. Whereas, T. conophorum extract recorded higher phenol content (52.3GAE/100g) compared with D. edulis extract (22.5GEA/100g). The flavonoids content of T. conophorum extract was comparable to that of D. edulis. The hepato-protective effects of the extracts were examined in vivo in male Wister rats challenged with sodium arsenate. Results showed that the rats fed with the two extracts had significant reduction (p<0.05) in lipid peroxidation, increase in SOD and catalase activities relative to control values. These results suggest that rat fed with Dacryodes edulis and Tetracarpidium conophorum extracts possess varied degree of potent antioxidant activity and may serve as important sources of antioxidants in food, cosmetics and pharmaceutical industries.