There is dearth of information on the gene frequencies of ABO and Rhesus blood groups, secretor status, PTC taste perception and haemoglobin variants in Osun State, Nigeria and previous studies have been based on heterogeneous population. We wanted to have information on the frequency distributions of these traits in Osun State and among a homogeneous population. A total of 555 individuals comprising 308 male and 247 female indigenes of Ore community participated in this study. Participants’ blood samples were typed for ABO, Rhesus blood groups and haemoglobin genotype, saliva samples were analysed for ABH secretory status and PTC taste perception was determined using PTC strips. The frequencies of O, A, B and AB individuals were 41.6%, 30.8%, 21.6% and 6.0% respectively, those of Rh positive and Rh negative were 89.9% and 10.1%, those of secretors and non-secretors were 69.2% and 30.8% respectively while those of tasters and non-tasters were 56.6% and 43.4% respectively. The observed ABO blood group, Rhesus factor, secretor status, PTC taste perception distributions did not differ significantly (p = 0.986, p = 0.943, p = 0.926, p = 0.864 respectively) from those expected under the Hardy-Weinberg equilibrium. The allelic frequencies for ABO were p(A) 0.205, p(B) 0.149 p(r) 0.645, those for Rhesus factor were D(0.682) and d(0.318), those for secretion and non-secretion were Se (0.445) and se(0.555) respectively while those of tasting and non-tasting were T(0.341) and t(0.659) respectively. Four haemoglobin genotypes in the order AA (68.6%) > AS (26.7%) > AC (3.8%) > SS (0.9%) were observed with allelic frequencies A(0.839), S(0.142) and C(0.019). This study has provided information on the frequency distributions of the studied genetic indices in Osun State. The information provided herein can be used to give medical and genetic counsel to the people of the State.