This study examined the watering regime that will enhance best germination and early seedling growth of Tetrapleura tetraptera. Seeds and seedlings of the plant were subjected to five different watering regimes viz: watering once weekly with 50ml, watering twice weekly with 50ml, watering once weekly with 100ml, watering twice weekly with 100ml and watering with 100ml only on the day of planting (as control for the seeds experiment), no watering (as control for the seedling experiments). The results of the experiment showed that watering once weekly with 100ml was the most effective watering regime for enhancing seed germination. This resulted in 85% germination, followed by the seeds watered twice weekly with 50ml (65%) and watering twice weekly with 100ml (50%). Other watering regimes were less or not effective. While watering twice weekly with 100ml was the most effective watering regime for enhancing seedling growth in this plant. This resulted in significantly highest plant height, number of leaves and broadest leaf area (22.00 cm, 15.00 and 27.51cm2 respectively) at the third month of planting. It also resulted in highest seedling stem girth (3.50 cm) though this was not significantly different from seedling treated with other watering regimes except for seedling treated with no watering which gave 0.20 cm. The results of these studies demonstrated that water supply may be a limitation for raising Tetrapleura tetraptera in the nursery as the soil moisture influenced germinability and early growth of this plant.