This paper with use descriptive-analytic method intends to explain spatial injustice in Iran. Spatial injustice refers to the imbalanced distribution of valuable political, social and economic power, wealth, infrastructures and opportunity resources. From political geography point of view, spatial injustice can be a threat to the national integrity, national & domestic security and creation of critical areas in the state. Spatial injustice is an important feature of spatial organization in Iran, which is formulated on a core-periphery structure from the local to national scale. This paper seek to address the following questions: what are the effective factors in spatial injustice in Iran? What are the consequences of spatial injustice on Iran? The results show that the most important foundations of spatial injustice in Iran are inequality in the distribution of power, wealth and opportunity resources, weakness of the budgeting system, weakness of management of regional and local systems, the absence of spatial justice as a general demand and institutionalized centralization.Spatial injustice, on one hand, endangers peace and stability of the country and threatens legitimacy of the political system on the other hand. Issues such as divergence, armed conflict, drugs, terrorism are the main reflections of spatial injustice that Iran is involved on the national scale.