Increasing interest for availability of tangible, novel, added value and sustainable commercial exploitable of nature therapeutic compounds including those derived from marine sources have enriched a long history of research into Acanthaster planci Crown-of-thorns (COT) starfish biology, ecology, and the causes of their outbreaks. These are important aspects for a sustainable commercial optimization and exploitation of Acanthaster planci COT especially for health related agendas or therapeutic application. This manuscript thus seeks to outline present and future research strategy and works pertinent to Acanthaster planci COT locally and global focused on evidence-based optimised sustainable exploitation as well as refining management actions to improve the performance of control programs. Among deuterostomes, the regenerative potential is maximally expressed in echinoderms such as the Acanthaster planci COT; these animals can quickly replace most injured organs. In tandem to that, views for further gene related molecular characterization and chemical analysis of potential cell mediated protein from these marine invertebrates that have potential in medical and pharmaceutical therapeutics will be highlighted.