Polio vaccination rejection among Muslims of northern Nigeria came as a result of misconception, rumours and mistrust of the polio vaccines. This paper is premised on exploring the Muslim–focused cultural sensitivity in the polio vaccination campaign to solve the problem of polio rejection and enhance the acceptance of the antigen as a preventive measure against poliomyelitis. The data was collected through in-depth interviews. 12 key informants comprising of physicians, traditional leaders and Islamic clerics were therefore selected purposively among the Muslim parents with children eligible for polio vaccination in northern Nigeria's states of Kaduna, Kano and Plateau. The findings revealed that Muslim-focused cultural sensitivity in polio vaccination messages and communication campaign will help to remove misconception and rumours about polio vaccination safety and efficacy in Northern Nigeria. It also established that the involvement of the Islamic clerics in the polio campaign will help to educate the Muslim parents to accept the polio vaccination for their children. The study concludes that there is the need to employ Islamic clerics as community mobilisers for polio vaccination campaign to reach out to communities and settlements for the sensitisation of the parents using Muslim-focused polio messages in interpersonal communication situations.