This research deals with the effect of integrating Directed Reading Thinking Activity (DRTA) strategy with vee diagram on students’ reading skill. This research was conducted in UMN Alwashiliyah Medan in which the population was all semester II English students. Two classes with 30 students for each were selected as the sample of the research. To achieve the aims of the research, quantitative research method was applied with true experimental design. Vee diagram test was used as the instrument of the research. The study showed that the integration of Directed Reading Thinking Activity strategy with Vee diagram significantly affected students’ reading skill. The data obtained also showed that implementing Directed Reading Thinking Activity with Vee diagram significantly affected students’ reading skill.It could be inferred that as long as cognitive skill was activated by Directed Reading Thinking Activity with Vee diagram, students’ reading skill will be higher since reading is a cognitive process in which the students have to increase their cognitive aspect into (C5) synthesis and (C4) analyze in order to be able not only to understandbut also to interpret the text well.