The advent of Islam in the sixth century resulted in the formation of a new empire and a world civilization. With the rise of Islam, Muslims had made immense leaps forward in the area of Science and Technology. The Contribution of Islamic Civilization to Science and Technology from the 8th to 16th century is a noteworthy expansion in human antiquity. The Muslim Scientists not only conserved the ancient knowledge, but also transformed it into major new contributions to the basic science and technology. Muslim Scientists significantly contributed to human knowledge in various fields through their innovations. This contribution was so great that Islamic civilization has been the pioneer of the scientific, intellectual and cultural genius for a long period of time. This paper, therefore analyses the contributions of Islamic Civilization with particular references to sciences. It affirms that Islam is beyond only the religion of prayers and rituals. This paper will also try to shed a light on few works that have been carried out by the Muslim Scientists with a brief explanation on their work on applied sciences like Mathematics, Astronomy, Chemistry, Physics, Medicine and other branches of modern science.