Indiscriminate usage of Cassia occidentalis in treating many diseases has been locally practiced, the need for ascertaining the epicacy of the extract in management of liver and kidney damage become imperative. This research investigate the effects of aqueous root extracts of Cassia occidentalis on some liver and kidney parameters in acetaminophen induced liver and kidney toxicity. A total of thirty five rats were used for the research, in phase I, ten rats were used to confirm the inducement of hepato-renal toxicity by acetaminophen. They were grouped into two of five rats each, group I serve as normal control, group two serves as test control and administered with 750mg/kg body weight of acetaminophen. The animals were euthanized after 24 hours of acetaminophen administration and liver function indices (ALT, AST, total protein, Albumin total and direct Bilirubin) and kidney function indices (urea and creatinine) were assayed. In phase II, twenty five rats were grouped into five groups (GI – GV) of five rats each. G I served as normal control, GII served as test control, GIII, GIV and GV were induced with hepato-renal toxicity and administered with the extract at a dose of 50mg/kg, 100mg/kg and 150mg/kg body weight per day for two weeks. A significant increase (p<0.05) in both liver and kidney function indices was observed in test control group compared to normal control in both phases. Administration of the extract lead a significant decrease (p<0.05) in liver parameters in a dose dependent manner compared to test control. Contrary to this however, a slight decrease in serum urea and creatinine was observed in the extract administered groups. The observed hepatocurative ability of the plant may not be unconnected with the presence of various phytochemicals in the plant.