This study was designed to investigate the influence of Postate cancer awareness campaigns on the knowledge, attitude and practices of men in SouthEastern Nigeria. The study employed the survey method of enquiry. The population of the study is 8,184,951 adult males in South-Eastern Nigeria. Five research questions guided the study. The data was analysed using Statistical Package for Social Science (SPSS). The result of the data analysed revealed that the awareness and knowledge level on postate cancer is relatively low among the men in South-Eastern Nigeria. Also, most information on postate cancer were made known to the respondents by medical practitioners, however, those respondents that are exposed to the campaigns agreed that the campaigns have influenced their behavior positively. The study recommends that, awareness campaigns should be well structured both in English and the target audience local language to sufficiently and effectively convey the Prostate cancer campaign messages. Thus, the risks and the effects of the negative attitudes of men towards this campaigns must obviously be stated citing relevant examples. Also, campaign planners should involve the target audience/opinion leaders as participants in the campaign and too, lower the age for screening, so that early detection and prevention can be detected before it becomes late. There must always be emotional, physical and psychological appeal in the campaign messages.