The purposes of this research were to investigate the implementation of screencast o matic integrated with inquiry learning for improving students’soft skill which focused on developing students’ self-confidence in speaking English and to investigate the interaction occured among variables. Quantitative research method was used with true experimental design in order to achieve the aims of the research. Semester IV students of English Department of Muslim Nusantara Al-Washliyah University were chosen as the sample of the research and divided into 30 students for experimental class I and 30 students for experiment class II. The data found was anlayzed by applying ANAVA (General Linear Models), normality test (one sample Kolmogorov Smirnov) and homogeneity test (One way Anova) with SPSS 22 IBM for Windows and MS. Excel in order to explore score obtained from each formulated indicator. The finding showed that the implementation of screencast o matic using inquiry learning significantly develops students’ self-confidence, eventhough there was no interaction occured between students’ self confidence and speaking with Sig> 0.05. The obtained data showed that developing self-confindence through screencast o matic integrated with inquiry learning with Sig > 0,05 (0,776 > 0,05). In short, the students’ speaking skill taught with screencast o matic sofware was higher, but students’ self-confidence was not developed by that software as students were a bit hard to adapt using screencast o matic software that never be used by them in advance.