Choice of science based careers by female students in Technical and Vocational Education and Training (TVET) institutes and particularly Technical and Training Institutes (TTIs) has attracted a lot of attention of education planners, economists and administrators the world over. Female students choosing careers in TVET science programmes are still few and especially in Siaya County, Kenya. The study was based on social Cognitive. The study adopted descriptive survey design. The research instruments were questionnaires the sample size was 316 female students sampled using census method. Tools in the Statistical Package for Social Sciences (SPSS) version 22 was used to analyze data. Frequencies, percentages and means were computed. Inferential statistics such as regression coefficients, T-statistics, F-statistics, correlation of coefficients shall were derived. Charts, graphs and tables were used to present the findings. It was found out that there exists a negative and statistically significant relationship between socio-cultural factors and female students‟ choice of career in science TVET Programmes (r=-0.546**; p<0.01). The significance of this study is that the findings could be used to come up with policies on how to increase the number of female students choosing careers in TVET. This could guarantee employment opportunities for women in the country which in turn could raise their standard of living.