With the university reform of 1993, the government of Cameroon had a political will to endow each of the country‟s ten regions with a State university, or at least, a faculty. In this light, some regional capitals became hosts of State universities. Since 2014, the city of Bertoua, hosts an annex of to the Faculty of Legal and Political Sciences of the University of Yaoundé II, and recently the Higher Teacher Training College of the University of Ngaoundere. The establishment of university infrastructure requisitions land in urban centres or peripheries, dislodging populations especially autochthons and engendering socio-spatial changes. This is compounded by the fact that most often their land is not registered or legally secured. This poses problems of land ownership in Cameroon. The objective of this article is to show that endowing these cities with university infrastructure, a major land grabber, impoverishes the local population. To achieve this, related literature and regulatory texts were reviewed, and questionnaires administered to ascertain the procedures and impacts of eviction and compensation. The main premise of this study is that despite the fact that the local population receives compensation, in the medium and long terms they become poorer than before owing to loss of identity and socioeconomic prestige. Consequently, a revision of the land law to include a compensation procedure based essentially on an “eviction-relocation” model and an accompaniment of locals‟ reestablishment is imperative and seen as plausible solutions.