Tuberculosis is a chronic infectious disease affecting humans of all ages in all parts of the world. The primary site of infection commonly involves lungs, although it can affect any part of the body, including oral cavity. Although oral manifestations of tuberculosis are very rare, the disease can present itself in a variety of clinical appearances which may mimic malignancy clinically. Thus the oral physician plays a pivotal role in the identification and control of this condition by early recognition of lesions that may precede the detection of pulmonary form. Tuberculous involvement of oral cavity is a very rare finding even in areas and countries where Tuberculosis is endemic. We present one such case of 36 year old female who presented with non-healing ulcer in the right lateral surface of the tongue and floor of the mouth. This paper deals with the case of tuberculosis diagnosed on the basis of oral manifestations, there by emphasizing the importance of the oral physician in diagnosis of multisystem disorder.