The article investigates the relationship between possible measures to overcome gender differences and high profile jobs relating to institution policy change and development in selected Universities of Western Uganda. The study adopted an observational, cross-sectional exploration design with both quantitative and qualitative as paradigms in order to describe the data and its characteristics. Questionnaires and an interview guides were employed to gather information from the respondents. Data was analyzed using frequencies, percentages and bar graphs. Study findings showed that there was a positive correlation between addressing gender differences and top job positions in universities in western Uganda. The study suggested remedies like; that there is need to advertise and give scholarships to young and well qualified women to go and pursue further studies for their career development and for helping their organizations to grow. There is need to encourage girl child education through the practice of positive discrimination and affirmative action in society. The study recommend also the practice of gender mainstreaming for all academic institutions to avoid the problem of under representation of both sexes , sensitization of stakeholders for girl child education, encouraging female candidates to apply for higher job positions and addressing gender-imbalance through staff development.