Gnetum africanum, a common soup vegetable in Nigeria is also been used in the treatment of enlarged spleen, sore throats, deduction of pains of child-birth, antidotes to some forms of poison and snake bite. This study is to ascertain phytochemicals and minerals present in the leaves of Gnetum africanum in addition to in vitro antioxidant activities using standard procedures. The result of the phytochemicals present revealed the presence of flavonoids, saponins, tannins, alkaloids while the minerals present in mg/100g includes: calcium (423.20), magnesium (112.81), phosphate (83.44), zinc (2.53), sodium (37.82), potassium (86.10), copper (1.00), Iron (11.67) and chromium (0.52). In vitro antioxidant activities using reducing power activity and DPPH radical scavenging assays showed that as concentration of Gnetum africanum increases from 0.2mg/ml to 1.0mg/ml, reducing power ability and radical scavenging activity also increases. In conclusion, the presence of bioactive agents such as flavonoids as well as radical scavenging ability of Gnetum africanum gives credence to its usage in herbal medicine for treatment of various ailments.