Aims the study was to reveal the morphological changes of cells of human palatine tonsils (PT), atypical cells and trichomonas in PT of patients in diverse diseases. Cytological material of PT of 1300 patients (male, female, aged 13 - 85) has been examined. Specimens of PT's cells were obtained by scraping from PT and placed as smears onto microscopic slides, stained by Giemsa and observed by a light microscopy (patent No. 2 293 298 C2, Russian Federation, 2007). 280 patients had malignant solid tumours of different localization, 19 patients had leukemia, 30 were practically healthy, the rest had different infections and inflammation diseases. Trichomonas were revealed from PT of male patients with iron deficiency anemia (1), remote melanoma (2), leukemia (3), lung cancer (2), trichomonas vaginalis (1) and practically healthy men (30). These patients did not suspect they were infected by trichomonas. No any trichomonas were obtained from health patients. These data support the idea that the test should be made in the following cases: (1) Patients in trichomoniasis and in other sexual infections. (2) Patients in neoplasm. (3) Patients in anemia. (4) Patients in pulmonary diseases. (5) Patients-perverted. The test can help to diagnosis and adequate treatment of trichomoniasis and other diseases.