Hypertension recognized as silent killer, has strong relationship with hormones secreted by endocrine glands. Present study was carried out to access the level of estradiol and testosterone in male and female cardiovascular hypertensive patients and to affirm their relation with hypertension. Serum samples of Cardiovascular hypertensive patients were tested for the level of estradiol and testosterone. Male and female cardiovascular patients were recruited for this study who were having treatment in District Head Quarter hospital. Estradiol level was significantly higher (61.38pg/ml; P=0.000) in post-menopausal hypertensive females, while normal concentration (51.01pg/ml; P=0.351) was observed in ovulating hypertensive females. In cardiovascular hypertensive males elevated estradiol level (51.545pg/ml; P=0.004) was found. Level of testosterone was higher (4.509ng/ml; P=0.000) in post-menopausal hypertensive females. Testosterone level was also raised significantly (4ng/ml; P=0.000) in hypertensive females that were in ovulating phase. We observed low level of testosterone (P=0.020) in cardiovascular hypertensive males. The level of the reproductive hormones was not normal range in females and males cardiovascular hypertensive patients. Level of the testosterone was lower in males suffering from hypertension while raised in female hypertensive patients that can lead towards problems in their marital life.